Androctonus Crassicauda Venom Scorpion

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Buy Androctonus Crassicauda Venom Scorpion from the best online supplier. Scorpion sting is the most important arachnidan envenomation that causes adult morbidity and child mortality. It remains a real health problem in many countries from tropical and subtropical regions (4, 13, 14, 15, 17, 20, 27).

Scorpion venom contains small neurotoxin polypeptides consisting of low-molecular-weight simple proteins with lethal and paralytic effects (1, 3, 15, 28). Several studies on scorpion stings emphasized that clinical pictures ranged from local to severe autonomic and central nervous system symptoms and also death due to cardio and respiratory failure, especially in children (5, 7, 10, 11, 12, 17, 18, 21, 22). Lethal scorpions are mostly of the Buthidae family (16, 18, 27).

In Turkey, scorpion envenomations are mostly caused by the genera Androctonus, Leiurus, and Mesobuthus (18, 19). In the same country, A. crassicauda venom, obtained by maceration of telsons, is utilized as an antigen for antivenom. This antigen has also been used against other scorpion species (23, 24). Therefore, the aim of this study was to verify the relationship between A. crassicauda venom toxicity and its telson size, weight, and storage condition.

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The purpose of the study was to examine the cytotoxic and anti-cancer properties along with addressing the plausible pathway followed by scorpion venom to reduce cell viability in SH-SY5Y and MCF-7 cells. Following exposure of cells to scorpion venom, cytotoxicity was estimated using MTT and lactate dehydrogenase assays.

Apoptotic effects were measured by assessment of mitochondrial membrane potential, reactive nitrogen species, DNA fragmentation, and caspase-3 activity whereas the antiproliferative effect was assayed using BrdU incorporation. Our results indicate that scorpion venom causes suppression of proliferation by arresting S-phase and induction of apoptosis through increased nitric oxide production, caspase-3 activity, and depolarization of the mitochondrial membrane.

Induction of apoptosis and arrest of DNA synthesis is critical determinant factors for the development of anti-cancer drugs. These properties may lead to the isolation of effective molecule(s) with potential anticancer activity from the scorpion venom of Androctonus crassicauda.